NeuroLines: a subway map metaphor for visualizing nanoscale neuronal connectivity

A. Al-Awami, J. Beyer, H. Strobelt, K. Narayanan, J. Lichtman, H. Pfister, M. Hadwiger
IEEE transactions on visualization and computer graphics, 20(12), pp. 2369-2378, (2014)

NeuroLines: a subway map metaphor for visualizing nanoscale neuronal connectivity

Keywords

Connectomics, Neuroscience, Data Abstraction, Multi-Trees, Focus+Context

Abstract

​We present NeuroLines , a novel visualization technique designed for scalable detailed analysis of neuronal connectivity at the nanoscale level.  The topology of 3D brain tissue data is abstracted into a multi-scale, relative distance-preserving subway map  visualization  that  allows  domain  scientists  to  conduct  an  interactive  analysis  of  neurons  and  their  connectivity.   Nanoscale connectomics aims at reverse-engineering the wiring of the brain. Reconstructing and analyzing the detailed connectivity of neurons and neurites (axons, dendrites) will be crucial for understanding the brain and its development and diseases. However, the enormous scale and complexity of nanoscale neuronal connectivity pose big challenges to existing visualization techniques in terms of scalability. NeuroLines offers a scalable visualization framework that can interactively render thousands of neurites, and that supports the detailed analysis of neuronal structures and their connectivity.  We describe and analyze the design of NeuroLines based on two real-world use-cases of our collaborators in developmental neuroscience, and investigate its scalability to large-scale neuronal connectivity data.

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